Date Title 1st author Journal



Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful   prognostic value in patients with multiple myeloma


 Kassambara A Haematologica


Identification of Pluripotent   and Adult Stem Cell Genes Unrelated to Cell Cycle and Associated with Poor   Prognosis in Multiple Myeloma


 Kassambara A PLoS One
01/08/2012 Antiangiogenic Therapeutic   Approaches in Multiple Myeloma  Ribatti D Current Cancer Drug Targets
18/10/2012 Development of gene expression   based score to predict sensitivity of multiple myeloma cells to DNA   methylation inhibitors  Moreaux J Molecular Cancer Therapeutics
27/10/2012 Dll1/Notch activation   contributes to bortezomib resistance  by upregulating CYP1A1 in multiple   myeloma.  Xu D Biochemical and Biophysical   Research Communications


Residual malignant and normal   plasma cells shortly after high dose melphalan and stem cell transplantation.   Highlight of a putative therapeutic window in Multiple Myeloma?


 Caraux A Oncotarget
01/12/2012 STEAP1 is overexpressed in   cancers: A promising therapeutic target  Moreaux J Biochemical and Biophysical   Research Communications


Pentraxin 3 (PTX3) inhibits   plasma cell/stromal cell cross-talk in the bone marrow of multiple myeloma   patients.


 Basile A.

Journal of Pathology


Multiple myeloma macrophages:   pivotal players in the tumor microenvironment


 Berardi S Journal of Oncology


The role of angiogenesis in   human non-Hodgkin lymphomas


 Ribatti D



Exome sequencing in tracking   clonal evolution in multiple myeloma following therapy.


 Weston-Bell N Leukemia


Kruppel-like factor 4 blocks   tumor cell proliferation and promotes drug resistance in multiple myeloma.


 Schoenhals M Haematologica


Tumor cells in multiple myeloma   patients inhibit myeloma-reactive T cells through carcinoembryonic   antigen-related cell adhesion molecule-6


 Witzens-Harig   MNeben K Blood


Inhibition of DEPDC1A, a bad   prognostic marker in multiple myeloma, delays growth and induces mature   plasma cell markers in malignant plasma cells


 Kassambara A PLoS One


Heparan sulfate proteoglycans in   the control of B cell development and the pathogenesis of multiple myeloma


 Reijmers, R M FEBS Journal


Novel targeting of phospho-cMET   overcomes drug resistance and induces anti-tumor activity in multiple   myeloma


 Moschetta M Clinical Cancer Research


The hypoxia target   adrenomedullin is aberrantly expressed in multiple myeloma and promotes   angiogenesis


 Kocemba K A Leukemia
21/08/2013 MHC Class I Antigen Processing   and Presenting Machinery: Organization, Function, and Defects in Tumor Cells  Leone P Journal of the National Cancer   Institute
01/09/2013 DNA repair pathways in human   multiple myeloma  Gourzones-   Dmitriev C Cell Cycle


Erythropoietin is involved in   the angiogenic potential of bone marrow macrophages in multiple myeloma


 De Luisi A Angiogenesis


Progression in Smoldering   Myeloma Is Independently Determined by the Chromosomal Abnormalities   del(17p), t(4;14), Gain 1q, Hyperdiploidy, and Tumor Load


 Neben K Journal of Clinical Oncology
26/12/2013 The Glycome of Normal and   Malignant Plasma Cells  Moehler T M PLoS One


Bone marrow vascular niche and  the control of angiogenesis in multiple myeloma


 Ribatti D Frontiers in Bioscience


DNA methylation score is   predictive of myeloma cell sensitivity to 5-azacitidine


 Moreaux J British Journal of Haematology


HIF-1  of Bone Marrow   Endothelial Cells Implies Relapse and Drug Resistance in Patients with   Multiple Myeloma and May Act as a Therapeutic Target


 Ria R Clinical Cancer Research



Bone marrow fibroblasts parallel   multiple myeloma progression in patients and mice: in vitro and in vivo   studies


 Frassanito   Dammacco M A Leukemia
01/05/2014 Microenvironment and multiple   myeloma spread  Ribatti D Thrombosis Research


A DNA repair pathway score   predicts survival in human multiple myeloma: the potential for therapeutic  strategy


 Kassambara A Oncotarget


IL-6 supports the generation of   human long-lived plasma cells in combination with either APRIL or stromal   cell-soluble factors


 Jourdan M Leukemia
01/08/2014 Role of endothelial progenitor   cells in cancer progression  Moschetta M Biochimica et Biophysica Acta -   Reviews on Cancer


Therapeutic targeting of the  mTOR-signalling pathway in cancer: benefits and limitations


 Moschetta M British Journal of Pharmacology


Cancer Associated Fibroblasts   and Tumor Growth: Focus on Multiple Myeloma


 Veirman K Cancers


Preclinical efficacy of   sepantronium bromide (YM155) in multiple myeloma is conferred by down   regulation of Mcl-1


 Wagner V Oncotarget
01/10/2014 Macrophages in multiple myeloma  Ribatti D Immunology Letters


A HGF/cMET Autocrine Loop Is   Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent  a Novel Therapeutic Target


 Ferrucci A Clinical Cancer Research


Stimulation of invariant natural   killer T cells by α-Galactosylceramide activates the JAK-STAT pathway in   endothelial cells and reduces angiogenesis in the 5T33 multiple myeloma model


 Haneen N British Journal of Haematology
08/12/2014 Myeloid-Derived Suppressor Cells as Therapeutic Target in Hematological Malignancies  Veirman K Frontiers in Oncology
01/01/2015 Identify multiple myeloma stem   cells: Utopia?  Saltarella, I World Journal of Stem Cells


GenomicScape: An Easy-to-Use Web   Tool for Gene Expression Data Analysis. Application to Investigate the   Molecular Events in the Differentiation of B Cells into Plasma Cells


 Kassambara, A PLoS Computational Biology


Cellular uptake kinetics of   bortezomib in relation to efficacy in myeloma cells and the influence of drug   transporters


 Clemens, C Cancer Chemotherapy &   Pharmacology


In vivo treatment with   epigenetic modulating agents induces transcriptional alterations associated   with prognosis and immunomodulation in multiple myeloma


 Maes K Oncotarget
20/02/2015 Cancer associated fibroblasts in   hematological malignancies  Raffaghello L Oncotarget


The 7p15.3 (rs4487645)   association for multiple myeloma shows strong allele-specific regulation of   the MYC-interacting gene CDCA7L in malignant plasma cells


 Weinhold N Haematologica


Drug metabolism and clearance   system in tumor cells of patients with multiple myeloma


 Hassen W Oncotarget


Association of Antigen-Specific   T-cell Responses with Antigen Expression and Immunoparalysis in Multiple   Myeloma


 Fichtner S Clinical Cancer Research


Multiple myeloma induces Mcl-1   expression and survival of myeloid-derived suppressor cells


 De Veirman K Oncotarget


Massive parallel IGHV gene   sequencing reveals a germinal center pathway in origins of human multiple   myeloma.


 Cowan G Oncotarget


Myeloma cells act as tolerogenic   antigen-presenting cells and induce regulatory T cells in vitro



 Frassanito MA European Journal of Haematology
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